After playing college basketball at the University of Tulsa, Ruffin was drafted in the second round of the 1999 NBA Draft by the Chicago Bulls. He has played for the Bulls, the Philadelphia 76ers, the Utah Jazz and Washington Wizards. Ruffin has averaged two points and 4.4 rebounds per game through his career but is considered to be a defensive presence on the court. He is known for his blocks and hard dunks. He is a fan favorite in Washington, and Wizards fans have nicknamed him "Beast".