After three years at Iowa State, where Fizer was a Sporting News All-America Second Team selection as a junior, he was selected with the fourth pick of the 2000 NBA Draft by the Chicago Bulls. Many analysts suspected that the Bulls had drafted Fizer merely to trade him for another player, since the Bulls already had Elton Brand playing at power forward. However, no such trade ever took place, and Fizer spent the next four years struggling to find a niche with the Bulls. He never averaged more than 12.3 points per game, and in 2004 he was made available in the 2004 expansion draft by the Charlotte Bobcats. Not making their final roster, he signed as a free agent with the Milwaukee Bucks. However, after one disappointing season in Milwaukee, he failed to sign a free agent deal with an NBA team. In November of 2005, he signed with the Austin Toros of the NBA Development League. On March 8, 2006, Fizer signed a 10-day contract with the Seattle SuperSonics of the NBA. On March 31, 2006 Marcus Fizer was named the NBA Development League MVP for the 2005-2006 season. Also on March 31, 2006 he was signed to a 10-day contract with the New Orleans/Oklahoma City Hornets.